Pharma
Excipients as Preservatives
Produced for Functionality
Excipients fall into several broad categories:
- Bulking Agents make the dosage form larger in size so that it becomes easier to manufacture and for patients to handle.
- Binders, which are also used in our granules for direct compression (DC), are utilized to facilitate the granulation process to make powders easier to compress.
- Glidants help the powders flow finally from the hopper to the capsule or tablet cavity and minimize friction and cohesion between particles.
- Lubricants are often used in combination with glidants to reduce the stickiness of powders or granules to the dyes or punches during compression.
- pH-Adjusters modifies the acidity in order to stabilize the drug substance in parenteral dosage forms or optimize the taste and disintegration in oral effervescent tablets.
According to scientific literature, select mineral salts also have an interesting effect as Preservatives, preventing degradation and helping to achieve sufficient shelf stability. Excipients as Preservatives Mineral salts produced by Dr Paul Lohmann® are not approved for use as active pharmaceutical ingredients or as antimicrobials in the USA.
| Product | Physical appearance | Quality | Solubility | 20 °C |
|---|---|---|---|
| Calcium Acetate | powder | Ph.Eur.; Low in Endotoxins | + |
| Calcium Acetate | powder | FCC | USP | + |
| Calcium Acetate | powder | Ph.Eur. | BP | ACS | + |
| Calcium Acetate | fine powder | USP | + |
| Calcium Acetate | fine granules | USP | FCC | + |
| Calcium Acetate | granules | USP | FCC | + |
| Calcium Acetate | granules | Ph.Eur. | USP | BP | + |
| Calcium Lactate | granular powder | Ph.Eur. | USP | FCC | + |
| Calcium Lactate | granules | Ph.Eur. | + |
| Sodium Acetate, anhydrous | powder | USP | FCC | + |
| Sodium Acetate, anhydrous | free flowing powder | E 262(i); with 0.2 % anti-caking agent | |
| Sodium Acetate, anhydrous | granules | USP | + |
| Sodium Acetate 3-hydrate | crystals | Ph.Eur. | USP; Low in Endotoxins | ++ |
| Sodium Acetate 3-hydrate | crystals | Ph.Eur. | USP | FCC | ++ |
| Sodium Benzoate | micronized powder | Ph.Eur. | FCC | NF | + |
| Sodium L-Lactate | solution; approx. 50% | Ph.Eur. | USP | solution |
| Sodium L-Lactate | solution; approx. 50% | Ph.Eur.; Low in Endotoxins | solution |
| Sodium L-Lactate | solution; approx. 60% | Ph.Eur. | USP | solution |
| Sodium L-Lactate | solution; approx. 60% | Ph.Eur. | USP; Low in Endotoxins | solution |
| Sodium L-Lactate | solution; approx. 70% | Ph.Eur. | USP | solution |
| Sodium Propionate | crystals | Ph.Eur. | FCC | NF | + |
| Sodium Propionate | granules | Ph.Eur. | FCC | + |
| Zinc Oxide | powder | USP | — |
Due to the chemical nature of Mineral Salts, Dr. Paul Lohmann® products are mostly used for functionalities beyond the above mentioned examples. Since Dr. Paul Lohmann® Mineral Salts are an integral component of pharmaceutical drugs, its excipients fulfill IPEC (International Pharmaceutical Excipients Council) and ISO 9001 guidelines.
With a flexible, innovative spirit, DPL responds to the changing needs of their business partners and clients, creating new solutions for modern manufacturing.